Enforcing CODEOWNERS based on merge request title

Is it possible to enforce CODEOWNERS for specific users based on merge request title?
For example: We use $CI_COMMIT_TITLE CI/CD variable to enable/disable certain jobs from running in the pipeline when specific values are present. Curious if there is a way to use the same CI/CD variable to require MR approval from specific users when a specific value is present in the merge request title?